Cell Immortalization
Author | : Alvaro Macieira-Coelho |
Publisher | : Springer Science & Business Media |
Total Pages | : 224 |
Release | : 1999-09-17 |
ISBN-10 | : 3540656189 |
ISBN-13 | : 9783540656180 |
Rating | : 4/5 (89 Downloads) |
Download or read book Cell Immortalization written by Alvaro Macieira-Coelho and published by Springer Science & Business Media. This book was released on 1999-09-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera tive phenotypes has to be seen using the perspective of comparative biology.