Download or read book Exploring the Clinical Implications of Brain-derived Neurotrophic Factor (BDNF). written by Dr.Hakim Saboowala and published by Dr.Hakim Saboowala. This book was released on 2022-01-06 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the Clinical Implications of Brain-derived Neurotrophic Factor (BDNF). Brain-derived neurotrophic factor (BDNF) is one of the neurotrophic factors that support: · Differentiation, · Maturation, and · Survival of Neurons in the Nervous System and shows a Neuroprotective effect under adverse conditions, such as: · Glutamatergic stimulation, · Cerebral ischemia, · Hypoglycemia, and · Neurotoxicity. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. BDNF and insulin-like growth factor-1 have similar downstream signalling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss. Thus, an attempt has been made in this E-Booklet to describe everything about BDNF elaborately along with several relevant ILLUSRATIONS for better understanding! …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)