The DNA, RNA, and Histone Methylomes

The DNA, RNA, and Histone Methylomes
Author :
Publisher : Springer Nature
Total Pages : 624
Release :
ISBN-10 : 9783030147921
ISBN-13 : 3030147924
Rating : 4/5 (21 Downloads)

Book Synopsis The DNA, RNA, and Histone Methylomes by : Stefan Jurga

Download or read book The DNA, RNA, and Histone Methylomes written by Stefan Jurga and published by Springer Nature. This book was released on 2019-08-28 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


The DNA, RNA, and Histone Methylomes Related Books

The DNA, RNA, and Histone Methylomes
Language: en
Pages: 624
Authors: Stefan Jurga
Categories: Medical
Type: BOOK - Published: 2019-08-28 - Publisher: Springer Nature

DOWNLOAD EBOOK

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations
Methylation
Language: en
Pages: 311
Authors: Anica Dricu
Categories: Medical
Type: BOOK - Published: 2012-11-28 - Publisher: Inst za onkologiju i radiol

DOWNLOAD EBOOK

Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, a
Polypharmacology
Language: en
Pages: 870
Authors: Zhiguo Wang
Categories: Medical
Type: BOOK - Published: 2022-08-01 - Publisher: Springer Nature

DOWNLOAD EBOOK

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, t
Applied Epigenomic Epidemiology Essentials
Language: en
Pages: 332
Authors: Laurens Holmes, Jr.
Categories: Medical
Type: BOOK - Published: 2023-12-01 - Publisher: Taylor & Francis

DOWNLOAD EBOOK

This applied clinical medicine and public health text introduces the fundamental concepts in epidemiological investigation and demonstrates how to integrate eme
Environmental Epigenetics
Language: en
Pages: 327
Authors: L. Joseph Su
Categories: Medical
Type: BOOK - Published: 2015-05-18 - Publisher: Springer

DOWNLOAD EBOOK

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included