Download or read book Cancer Drugs Targeting DNA Replication: Molecular Strategies to Enhance Specificity and Efficacy written by Yizhu Li and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The DNA molecule stands at the center of cancer origin and treatment. Cancer cells are addicted to DNA mutations and DNA replication, therapeutic non-responders are often based on the rate of mutations and ability to replicate DNA. Conversely, DNA, being the most vulnerable spot of a tumor, is also the main target for chemotherapies. The in-depth understanding of cellular processes upon errors in the DNA genetic code is therefore crucial for designing new chemotherapeutic drugs and new combinations of drugs; specifically, it is the main endeavor to induce and exacerbate DNA damage in cancer...