Download or read book From Globular Proteins to Amyloids written by Irena Roterman-Konieczna and published by Elsevier. This book was released on 2019-10-02 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Globular Proteins to Amyloids proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations.