Download or read book Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences written by Pierre R. Bushel and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results ) and brings together analyses that combine gene expression (microarray, TempO-Seq or RNA-Seq) with other data (biological assays, clinical chemistry, therapeutic categories or molecular pathways) or highlights data analytics that leverage bioinformatics and statistics. The eight articles illustrate the state-of-art in the field and the analysis of toxicogenomics data for a more comprehensive deduction of biological mechanisms and cellular functions associated with adverse outcomes from environmental exposures, chemicals and toxicants. However, it is clear that the field of integrative toxicogenomics needs considerably more attention paid to it in order to develop other clever ways of integrating the data for analysis.