Download or read book Interaction of Aziridines With Cellular Components (Classic Reprint) written by Jerry B. Stokes and published by Forgotten Books. This book was released on 2018-03-18 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excerpt from Interaction of Aziridines With Cellular Components During the past 30 years much work has been done on'the mechanism of action of biologically active alkylating agents, and the results of this work have made evident the extreme complexity of the topic. Nitrogen mustards dominate much of the work on biological effects of alkylating agents, with other compounds belonging to the same class aziridines, sulfonic acid esters, and epoxides-appearing less frequently. Nevertheless, broad generalizations about the biological effects and biochemical mechanisms of all biological alkylating compounds have been and still are frequent. During World war I and the postwar period, workers (lynch et al. 1918, Pappenheimer and Vance 1920, Flury and Wieland 1921) investigating the vesicant properties of mustard gas realized that it and related chemicals possessed unusual biological properties. Marshall (1919) proposed that the action of mustard gas was due to its rapid penetration into the cell, hydrolysis within the cell to generate hydrochloric acid, and subsequent destruction of some mechanism or part of the cell by hydrochloric acid. However, Peters and walker (1923) demonstrated that there was no correlation between the rates of liberated acid and the vesicant action of mustards. In the midthirties. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.